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KMID : 0356620070220020105
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Journal of Korean Society of Endocrinology
2007 Volume.22 No. 2 p.105 ~ p.111
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Galectin-3 and Thyroid Peroxidase Expression in Thyroid Nodules
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Bae Gyu-Hwan
Lee Sun-Ah
Kim Hyun-Sook
Kim Myung-Hwan
Jung Eui-Dal
Sohn Ho-Sang
Yoon Hyun-Dae
Bae Jong-Yup
Hong Sung-Pyo
Ahn Sun-Young
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Abstract
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Background : The accurate diagnosis of a thyroid nodule is important in deciding a patient’s treatment plan and for predicting the prognosis. The histopathological diagnosis of resected specimens are largely positively accomplished, but the consistency of the diagnosis is low when the specimen shows a small carcinomatous cytological feature or the nodule does not express papillary proliferation. Therefore, the need for supplementary diagnostic measures is increased. Herein, the expressions of galectin-3 and thyroid peroxidase (TPO) of resected specimens were investigated using immunohistochemical staining, and their potential for contributing to an accurate diagnosis studied.
Methods :The specimens included 195 resected thyroid nodules obtained from 179 patients having undergone thyroid surgery. Immunohistochemical staining for two useful antibodies, galectin-3 and TPO, were performed, and the expressions of these two antibodies investigated with regard to the histological diagnosis.
Results : The sensitivity, specificity, and positive and negative predictive values of galectin-3 and TPO for detecting papillary carcinomas were all 100%, but these values were low for other forms of carcinoma.
Conclusion :Our data showed the diagnosis of thyroid nodules, using immunohistochemical staining for galectin-3 and TPO, was very useful for detecting thyroid papillary carcinoma, but insufficiently sensitive for follicular carcinoma. Immunohistochemical staining for TPO is also useful for distinguishing cases when a false positive result for galectin-3 is obtained.
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KEYWORD
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Galectin-3, Molecular markers, Thyroid nodules, Thyroid peroxidase
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